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The main practical drawbacks are cost, a more complex dosing routine, and the fact that you are adding Dihexa, the least-evidenced and least safety-characterized component

When the same study was repeated 10 years later with Australian 8-10 year olds, the prevalence of wheeze had increased from 10.4% in 1982 to 27.6% in 1992 in Belmont and from 15.5 to 23.1% in Wagga Wagga

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A holistic evidence package combining surrogate data with real-world evidence and patient-reported outcomes is critical to reduce uncertainty, strengthen pricing negotiations, and secure market access