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Surgery (Wide Local Excision) Removal of cancerous tissues or gland ( See Wide Local Excision for Treatment of Melanoma The main treatment options of most sarcomas Addresses the treatment area and a small portion of the surrounding area May be a final treatment for some tumors May involve removal of lymph nodes near the primary tumor Can be utilized with other types of treatment Radiation Focused beams of energy that disrupt tumor growth by damaging the DNA of the cancer ( See Radiation Therapy for Melanoma Can be given before or after surgery, and in different ways Typically used in larger, higher-grade tumors Often used to treat an area where the cancer is likely to recur Can be utilized with other types of treatment Chemotherapy Drug treatment that addresses cancers that have or can spread to other areas ( See Chemotherapy for Metastatic Melanoma ) Works to inhibit cancer cell growth Used effectively for some subtypes of sarcoma Can be given orally, intravenously, or in other ways Doses are carefully selected to target the specific type and stage of the cancer Can be utilized with other types of treatment Targeting Therapy (Precision Medicine) Drug treatments that seek very particular proteins or enzymes within cancer cells( See Melanoma Targeted Therapy ) Inhibits cancer cell replication and growth Targets specific genes and proteins Can mark cancer cells so that they can be destroyed by the immune system Can prevent new blood vessels from forming that can boost tumor growth Can be utilized with other types of treatment Immunotherapy Helps to fight cancers by helping the body defend itself ( See What is Immunotherapy for Cancer

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At higher doses (e.g., 25 mg/day), patients exhibited increased serum ALP and ALT/AST levels (Nevens et al., 2016)

In trials, 15.8% of those taking 0.5 mg doses reported nausea

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Based on HMRD and virus-free clinical impairments of different human organs/systems, PASC patients can be categorized into 4 different clusters or sub-phenotypes: sub-phenotype-1 (33.8%) with cardiac and renal manifestations