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RSL3 suppresses viability in thyroid cancer cell lines To determine whether GPX4 inhibition affects tumor cell viability, we treated PTC cells with various concentrations of RSL3 and performed a cellular viability assay

In contrast to HO-1 knockdown, HO-1 overexpression significantly upregulated ferroptosis-related indexes, such as Fe 2+ , ROS, C11-BODIPY and MDA levels, but decreased GSH content (Fig

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