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Stay at the current dose until GI symptoms have resolved for at least two full weeks

This echoes the findings of a 2013 review, which found neither firm evidence in favor of this hypothesis nor evidence strong enough to rule out any such increased risk. Recent research also points to a link between the GLP-1 receptor agonist semaglutide and worsening diabetic retinopathy (DR)

The glucagon receptor activation in Retatrutide contributes to increased energy expenditure and enhanced fat oxidation

doi: 10.1111/bcp.14514 70 VerdecchiaP.CavalliniC.SpanevelloA.AngeliF

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The stepped dosing approach is now standard clinical practice because it optimizes both efficacy and tolerability over time