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The answer is that, although the high-valent metal-oxo heme cores of these intermediates are in fact very similar, the substrate-binding cavities seem to differ substantially in how much access the substrate has to the iron center

Regarding blood pressure, isoprenaline control rats exhibited intracranial (superior sagittal sinus) hypertension, portal and caval hypertension, and aortal hypotension

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234 This has inspired the exploration of new modification technologies to reduce the adverse effects associated with PS modification