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However, it has also been suggested that abnormally high values of circulating irisin may be associated with increased risk factors for cardiovascular disease (Calan and Demirpence, 2019) and may predict major adverse cardiovascular events in patients with acute coronary syndrome (ACS) (Table 3

Preclinical studies showed lipolytic and anti-lipogenic effects, but human trials failed to demonstrate significant weight-loss outcomes

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Key benefits and findings include: Antioxidant Action: PLE reduces oxidative stress, a critical factor in melasma, by neutralizing free radicals and minimizing UV-induced inflammation

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