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Endocrinology 148 , 12061217 (2007)

For finer staging and detection of steatohepatitis, disease activity, or early fibrosis, markers such as cytokeratin-18 (CK-18), N-terminal propeptide of collagen type 3 (PRO-C3), and omics-based profiles (transcriptomic or lipidomic) can be used [74, 75]

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Phosphorylation of the DSGIS motif in NRF2 mediated by glycogen synthase kinase-3 beta (GSK-3) promotes the binding of -TrCP to NRF2 which is therefore marked for ubiquitination and then degraded by the proteasome [145, 149,150,151]

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