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Moreover, it also reduces the protein levels of PI3K, Akt, mTOR, and Ras, Raf, and p-ERK, indicating that H 2 S may regulate human TNBC cells through dual targeting of the PI3K/Akt/mTOR and Ras/Raf/ERK signaling pathways 369 (Fig

J Agric Food Chem (2008) 56:78726.10.1021/jf801502z 55 ProcopioAAlcaroSNardiMOliverioMOrtusoFSacchettaPet alSynthesis, biological evaluation and molecular modelling of oleuropein and its semisynthetic derivatives as cyclooxygenase inhibitors

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Tirzepatide, for example, activates C/EBP alpha, which in turn upregulates expression of the tight junction protein claudin-1, thereby keeping the blood-brain barrier intact and functional