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EBioMedicine (2020) 52

Keshani et al

IGF1 inhibits starvation-induced cardiac autophagy via mTOR signaling in vitro , and negatively regulates cardiac autophagy and AMPK activity in vivo (Troncoso et al., 2012)

A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs

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Combining tirzepatide with hormone therapy adds roughly 35% more weight loss per Mayo Clinic ENDO 2025, especially relevant for hormonal belly fat redistribution