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Serum metabolomics reveals compatibility rules of the antidepressant effects of Xiaoyaosan and its efficacy groups

Keywords: primary senile degenerative dementia, alzheimers dementia, amyloid-, white matter, synaptic plasticity, methylene blue, hippocampal fibres, hippocampal ca1, axonal degeneration, alzheimer disease Introduction and background Alzheimer's disease (AD), the prevailing neurodegenerative disorder, is characterized by a progressive decline in cognitive abilities, ultimately resulting in profound dementia [1]

3.2.4 Developmental and drug-induced microbiome disruption Disruptions to the gut microbiome during early development or the initial phases of psychiatric illness may influence the trajectory of mental disorders (Lavebratt et al., 2019) reported that early-life antibiotic exposure is linked to modestly increased risks for several childhood psychiatric disorders, including mood disorders, suggesting sensitive developmental windows for microbiome perturbations (Lavebratt et al., 2019)

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