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Rigorous preclinical and clinical evaluations will be essential to determine their safety, efficacy, and potential contribution to improving reproductive outcomes in patients with DOR

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Overexpression of PINK1 can significantly upregulate Beclin1 and LC3 protein expression in an isoproterenol (ISO)-induced mouse cardiomyocyte injury model, decrease p62 protein expression, enhance myocardial mitophagy, and alleviate ISO-induced MMP reduction, ROS production, and cell apoptosis

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