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We used the 3xTg mouse model of AD, which expresses familial human isoforms of APP (APPSwe), Tau(tauP301L), and Presenilin (PS1M146V), and exhibits both A and tau pathology as well as cognitive deficits 13

The MHRA and European Medicines Agency (EMA) continue to monitor the safety profile of GLP-1 receptor agonists, with no established causal link to suicidality, though monitoring is ongoing

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