Bae, M.-A., Pie, J.-E
The gut microbiota, consisting of bacteria, viruses, archaea, protists, and fungi, is estimated to consist of approximately 10 13 -10 14 microorganisms, roughly 10 times the number of human cells in the body, and its collective genetic material surpasses the human genome by more than 100 times (Thursby and Juge, 2017
Bio Mater 3 (1), 704712
MEDI7247, an antibody-drug conjugate (ADC) that specifically binds to the extracellular domain of ASCT2, could release its payload pyrrolobenzodiazepine (PBD), promoting DNA damage and tumor cell death (Liu et al., 2018
Competing interests The authors have declared no competing interests
The available human evidence is limited to early phase-2 studies on postoperative ileus, as reported by Beck et al., 2014, and has not led to any authorisation