During the catalytic cycle of GPX4, the active selenol (-SeH) is oxidized by peroxides to selenenic acid (-SeOH), which is then reduced with glutathione (GSH) to an intermediate selenodisulfide (-Se-SG)
Mild stomach upset or constipation can occur but usually resolve on their own
Perez Y, Shorer Z, Liani-Leibson K, Chabosseau P, Kadir R, Volodarsky M, et al
Prices range from $40 to $80 per vial, putting the cost per milligram at $8 to $16
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