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Oral GLP-1 therapies eliminate the need for injections
Using a model of streptozotocin diabetes in rats in vivo and HT-22 cells in vitro, it was shown that GLP-1RA liraglutide improves the cognitive abilities of rats with diabetes mellitus and can have a protective effect by reducing oxidative stress, suppressing the expression of -secretase (BACE1) and -secretase, as well as reducing the deposition of -amyloid by triggering signaling mechanisms associated with NF-kB and ERK1/2 [30]
In some respects, the mechanism of GLP-1-MK-801 is similar to other therapies targeting GLP-1 receptors, in that it activates neural circuits involved in feeding, appetite, and reward
I mean, there's just so much we can learn here from the proteomics
It is well established that individuals with mental illness have a higher risk of suicide [14, 15]