Researchers working with this compound should remain mindful of the important scientific context outlined in this guide: no specific receptor has been conclusively identified, the evidence base varies in strength across the documented mechanisms, and the majority of published research derives from animal models with a significant proportion from a single research group
doi: 10.1177/153537020222701014
Blood J Am Soc Hematol 111(7):34793488 Liu J-M et al (2003) The tetrapeptide AcSDKP, an inhibitor of primitive hematopoietic cell proliferation, induces angiogenesis in vitro and in vivo

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First, the publication bias is an inevitable problem in any meta-analysis
However, the improved metabolic health and reduced body weight often normalize cortisol levels that were elevated due to obesity