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1 To help patients understand dosing with KESIMPTA, share the instructions below: Initial dosing of 20 mg by SC injection at weeks 0, 1, and 2, followed by subsequent dosing of 20 mg by SC injection once monthly starting at week 4

IV fluids address dehydration

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For patients with cardiovascular or kidney disease, SGLT2 inhibitors or GLP-1 receptor agonists (oral or injectable) may be considered as part of first-line therapy for their cardiorenal benefits

217 In another study, the deubiquitinating enzyme OTUD1 inhibited the NF-B pathway by interacting with RIPK1 and inhibited the excessive production of the proinflammatory cytokines TNF-, IL-6, and IL-1 in UC, thereby inhibiting colon inflammation