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Patient disposition for active-controlled RCTs (PIONEER 2 to 4), placebo-controlled RCTs (PIONEER 1, 5, 8), the CVOT (PIONEER 6), and the population-specific safety studies (PIONEER 9, 10) are presented in Table 23, Table 24, Table 25, and Table 26, respectively

Efficacy significantly surpassed respective monotherapies

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