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Studies: Muscle strength and hypertrophy: A meta-analysis published in the Journal of the International Society of Sports Nutrition found that creatine supplementation significantly improves strength and lean body mass in various populations

doi:10.1056/NEJMoa0804748 36

Gallo, V

generally no symptoms at rest, instead the symptoms usually start on standing or after walking a certain distance and this distance can vary from only a few metres to a few hundred metres