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M1 macrophages also release a large amount of pro-inflammatory factors, such as TNF-, IL-1 and other pro-inflammatory factors, which can cause peripheral and central sensitization, and then enhance the esophaguss susceptibility to a variety of reflux stimuli

As the primary structural component of the skin, collagen provides firmness and elasticity, which are essential for a youthful and healthy appearance

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Glutathione is a highly potent antioxidant

For example, mice with depleted gut microbiota-achieved through germ-free housing or antibiotic treatment exhibited reduced responses to CTLA-4 blockade immunotherapy