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These included: Nausea (the most frequently reported adverse effect) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent, occurring more frequently and with greater severity at higher doses

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Instead, he advised baseline retinal examinations in patients with diabetes before initiating therapy and closer monitoring for those with severe NPDR or proliferative DR during periods of rapid glycemic improvement (Figure 3)

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