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The probiotic group showed a significant reduction in white blood cell counts, TNF and IL-6 plasma levels, but this intervention did not alter DAS-28 (median of 3.83 at baseline vs a median of 3.88 at the end of the study in the placebo group

Michalon, A

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The trial enrolled 117 patients and reported that ipamorelin was well tolerated, with adverse-event rates similar between the treatment and placebo groups

Contraindicado en hipertiroidismo y tiene riesgo teratognico (requiere programa REMS y anticoncepcin efectiva)