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How Trulicity works Trulicity mimics one hormone called GLP-1 (glucagon-like peptide-1), which: Slows food movement through your stomach, helping you feel fuller for longer Communicates with your brains appetite centre to reduce hunger Improves blood sugar control by enhancing insulin function How Mounjaro works Mounjaro activates two hormone receptors: Like Trulicity, it activates the GLP-1 receptor It also activates GIP (glucose-dependent insulinotropic polypeptide), a second gut hormone involved in appetite and blood sugar regulation This dual-action is the primary reason Mounjaro produces greater weight loss and blood sugar improvements than GLP-1-only medications like Trulicity

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily licensed for the management of type 2 diabetes mellitus and, in specific cases, for weight management

And for patients who do eventually have surgery, GLP-1s are increasingly part of the picture before and after

Nephrol Dial Transplant 38(9):20412051 Ruze R, Liu T, Zou X, Song J, Chen Y, Xu R et al (2023) Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments

These medications work by activating GLP-1 receptors in pancreatic beta cells, the brain, and gastrointestinal tract

This hormone helps to slow digestion and promote feelings of fullness, which reduces appetite