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It has been found, using specific knock out (KO) mice and cultures, different specific activities for IRS-1 and IRS-2, additional further complexity comes with tissue-specific roles

A Potential Reduction of Cell Damage in Alcoholic and Nonalcoholic Fatty Liver Disease Fatty liver occurs when fat builds up around the organ, making it swell up and cause damage to the tissue and cells

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doi: 10.3389/fimmu.2021.821538 130 JungH

Yes, with appropriate caution