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Interestingly, GPX3 activity progressively decreased with age, which was more significant for people over 70 years old

FIGURE 7 Effect of GPX3 on stress-induced senescence model in rat tenocytes The role of GPX3 in cellular senescence was also investigated using the stress-induced senescence model created via treatment with H 2 O 2 (Figure 7G)

Inhibition of phosphofructokinase-1 will lead to a buildup of fructose-6-phosphate and glucose-6-phosphate, and the latter will further allosterically inhibit hexokinase