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Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control

Participants in the tablet trial lost an average of 13.6% of body weight at 64 weeks, while those in the injection trial lost 14.9% at 68 weeks

doi: 10.1016/j.jmb.2019.02.004 103 HeL.LiangJ.ChenC.ChenJ.ShenY.SunS.et al

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The intracellular imbalance between oxidant and antioxidant due to the abnormal expression of multiple redox active enzymes will promote the produce of reactive oxygen species (ROS)