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The FDA also recommends examining hard clinical endpoints such hepatic decompensations, transplant free survival, and all-cause mortality, although these results are not necessarily needed prior to drug approval given the long length of follow up potentially required

Two new actions of topiramate: Inhibition of depolarizing GABAA-mediated responses and activation of a potassium conductance

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Analysis of major organs (heart, kidneys, and liver) showed no detectable signals in any group ( Fig