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For patients with type 2 diabetes, NICE guidance recommends that GLP-1 treatment should be continued only if there is adequate improvement in HbA1c and weight after 6 months

The mechanism of action of the DMT must be considered, and bridging or de-escalation approaches might be necessary, especially when stopping blockers of immune cell trafficking, such as natalizumab and fingolimod 121

Vitamin b12, or cobalamin, is a cofactor the body cannot manufacture

This is the heart of the cAMP pathway

Liraglutide (Saxenda) Liraglutide works through the same GLP-1 pathway but has a different dosing schedule than other options on the market, requiring a daily rather than weekly injection

Losing weight can help to reduce fat accumulation in the liver and improve liver function