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Specifically, mutagenesis of ECD, ECL1 and ECL3 individually increased the basal activity of GCGR, which could result from the interruption of intramolecular interactions between the ECD and ECL1/3 that otherwise stabilize the receptor in an inactive state

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13 biomarkers including -catenin, C-MYC, GATA-4, CXCL13, DAPK1, TIMP3, DC-SIGN, EGFR, PIM2, GRIN2B, SLC5A8, VCAM-1 and CDH1 are related to the development of gastric cancer, and six of them including -catenin, DC-SIGN, C-MYC, EGFR, CXCL13 and PIM2 have been reported overexpressed in gastric tissue from infected children and gastric cancer patients (73)

43,44 Together these methods provide complementary strategies for capturing differentiation trajectories in aging MuSCs