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Author contributions UR, OB, GDN, RT, SSal, PS, and PPar conceived and planned this project inviting all the experts in this field from both the Italian Society of Pediatric Gastroenterology Hepatology and Nutrition (SIGENP) and Italian Society of Pediatric Neurology (SINP), they have also written the first draft of the manuscript

Before each injection, you should visually inspect the insulin in the pen

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Oxidative stress Lipid peroxidation Level To evaluate the LT stress-associated cellular membrane damage (MDA content), estimation in terms of TBAR formation was carried out

Treatment suitability still depends on the individual medication, diagnosis, medical history and prescribing information