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The main driving force for the transport of some flavonoids and anthocyanins into vacuole has been inferred to be a proton gradient between the cytoplasm and the vacuole (or the cell wall), which is maintained by H + -ATPases (and H + -PPases in the tonoplast

A standardized meta-analysis approach by Volkova et al

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10.1186/s12974-017-1004-5 79 NeherJ

Oral supplements have limited efficacy because much of the compound is broken down by the digestive system before it can be fully absorbed

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