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There is a boxed warning regarding thyroid C-cell tumors based on rodent findings, and these agents are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN 2)

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Symptomatic support and immunity improvement are currently the first-line approaches for the treatment of chronic inflammation, mainly because chronic inflammation is often acompanied by disorder of the immune microenvironment