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Sensory signals control the release of hypothalamic corticotropin-releasing hormone (CRH) and vasopressin (AVP) from the paraventricular nucleus and into the pituitary portal circulation, where they reach the adenohypophysis and stimulate the release of adrenocorticotropic hormone (ACTH), which in turn promotes adrenocortical production and cortisol release (74)

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www.ncbi.nlm.nih.gov , Molecular Pharmacology , vol

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Both categories have their unique advantages and complement each other in clinical practice

10.1016/S0891-5849(02)01009-2