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Notably, many confounding factors like medical treatment, drug intake, and dental plaque existence were not taken into consideration, which could reduce the credibility of the experiment

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In the present analysis, the effect size of the retreatment was based on the effect of the initial treatment course observed in the clinical trials, and this assumption was reviewed and validated by a specialist physician in obesity disease who is a board member of the Japanese Society for the Study of Obesity and has clinical experience in endocrinology and metabolism in Japan

LAG-1 and other CSL proteins share the same in vitro DNA binding site (GTGGGAA, LAG-1/CSL binding site hereafter) [16,18,19]

External factors, like friction from clothing rubbing against the injection site, can make irritation worse