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PYC has been shown to attenuate MTX-induced oxidative damage, reducing its off-target toxicities ( Following sepsis induction in Wistar albino rats, PYC treatment decreased malondialdehyde levels, increased GSH levels, and enhanced SOD and GPx activities

This phase II trial demonstrates that enobosarm, a selective AR modulator, shows anti-tumour activity and clinical benefit in women in postmenopause with ER-positive, HER2-negative and AR-positive advanced breast cancer, supporting further investigation of AR activation as a therapeutic strategy

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The broad anticancer activity and anti-metastatic properties observed in this study align with prior evidence of BVs effects across multiple tumor types [13]

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