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Digestive organoid biobanks and clinical studies Because various organoids can be easily obtained from postoperative or biopsy tissue and cultured indefinitely, many patient-derived organoids form the basis for the creation of living biobanks

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In recent GLP-1RA trials focusing on patients with obesity, favourable effect on worsening heart failure in HFpEF patients was indicated to be modulated by baseline BMI [32], although the underlying mechanisms that explain the cardiovascular and renal benefits may not necessarily be due to weight loss alone

In intestinal L-cells and neurons of the NTS, a predominance of PC1/3 expression, GLP-1, oxyntomodulin, and GLP-2 are seen as physiologically relevant (Tucker et al., 1996