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Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found

NME is characterized by erythematous erosive crusted or vesicular eruptions of papules or plaques with irregular borders (figure 13)

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Tier 2 (Grade 2 GI: interferes with daily activities, or any vomiting with fluid retention): Hold dose escalation

Horses would require supplementation every few hours to maintain efficacy