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3.2 Lactoferrin activates IRS-1/PI3K/AKT to improve insulin resistance Studies have shown that LF upregulates insulin receptor (IR), insulin receptor substrate-1 (IRS-1), glucose transporter 4 (GLUT4), PI3K and AKT in liver protein expression (30), increases peroxisome proliferator-activated receptor and regulatory protein SIRT-1 expression (28), and is negatively correlated with chronic inflammation-induced metabolic disorders of insulin resistance, hyperglycemia, and obesity, and positively correlated with insulin sensitivity (48)

Alamdari N, Aversa Z, Castillero E, Gurav A, Petkova V, Tizio S, Hasselgren PO

The Importance of Healthy Testosterone Levels for Men Testosterone plays a leading role in male vitality

Kar D, Pradhan AA, Datta S (2021) The role of solute transporters in aluminum toxicity and tolerance

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Handbook of soil acidity