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Oxidative stress biomarkers like malondialdehyde, 8-OHdG, or plasma antioxidant capacity can establish baseline status

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The debilitating fatigue which seems to be the most common symtpom of B12 deficiency may be due to a combination of neurological factors, anaemia, and the role of B12 in the mitochondria

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In cases of zinc deficiency, even short-term supplementation of in average 6 days can significantly improve immune function by decreasing CREM expression and thereby increasing IL-2 production [309]