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However, several drugs, including teprotumumab and BIIB-022, which target IGF-1R, have not shown good therapeutic effects in clinical trials, possibly due to the lack of reliable IGF-1R inhibition biomarkers

Physicians should also exercise caution when prescribing to patients with proliferative retinopathy or severe, uncontrolled diabetes, as GH can transiently affect insulin sensitivity

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First, we performed the OF test to exclude any influence of exploratory or locomotor activity on cognitive function evaluation