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Theres a real pharmacological explanation for why some patients feel the medication wearing off in the days before their next dose, and there are practical ways to manage it

Sulfonylureas: Another type of oral medication that stimulates the pancreas to release more insulin, helping to lower blood sugar levels

Originally developed for diabetes, medications like semaglutide and tirzepatide quickly gained fame for their dramatic effects on weight loss

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By delaying how quickly food leaves the stomach, the medication helps patients feel fuller for longer periods and reduces overall caloric intake