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People with kidney disease should avoid high doses of B vitamins.

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Why B12 Matters During Active Weight Loss During significant weight loss, your body undergoes metabolic shifts that increase demand for B vitamins

Some medications also reduce B12 absorption (Sobczyska-Malefora et al., 2021) among the main ones are: metformin, proton pump inhibitors (PPIs), such as omeprazole, lansoprazole and esomeprazole, and H2-receptor antagonists, such as ranitidine, cimetidine, famotidine and nizatidine

B12 Intramuscular Dose Recommendations The usual dose for vitamin B12 injections is 1000 mcg (1 mg)