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Uncontrolled free-radical damage is a key cause in diseases affecting the brain, including schizophrenia and Alzheimers

These include methods for direct reactive oxygen species (ROS) detection (e.g., superoxide, hydrogen peroxide), characterization of oxidative damage to lipids (e.g., TBARS, F2-isoprostanes

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However, to date, there is only one randomized clinical trial of GLP-1 RAs (the ELIXA study) evaluating major cardiovascular events as their primary outcomes, and in this study, a neutral cardiovascular effect of lixisenatide was observed in high-risk diabetic subjects

However, recent research suggests that this association may be more attributable to genetic inheritance between mother and child rather than a direct causal relationship [25]