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Correlation analysis revealed that CD8 + T cell, resting memory CD4 + T cells, Tregs, resting NK cells, Monocytes, and resting mast cells had the most apparent correlation with ferroptosis DEGs, indicating that the interaction of FRGs with immune cells may be the potential pathological mechanism leading to the onset and progression of LN

PMID: 142 HeviaAMilaniCLopezPCuervoAArboleyaSDurantiSet al

The proposed cascade is mechanistically coherent but empirically unvalidated