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In biological systems, over 95% of circulating native IGF-1 is sequestered in ternary complexes with IGF binding proteins (primarily IGFBP-3) and the acid-labile subunit (ALS), meaning only a small free fraction is available to activate IGF-1R at any given time

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Older GHRPs like GHRP-6 and Hexarelin elevate cortisol and prolactin via off-target signaling