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doi:10.1080/07315724.2012.10720431

Munoz-Perez E, Igartua M, Santos-Vizcaino E, Hernandez RM (2025) 3D-printed Laponite/alginate hydrogel-based suppositories as innovative platforms for AT-MSC secretome delivery in IBD treatment

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Anaesthesia & Intensive Care Medicine , 21 (10), 517-523

Too much estrogen being metabolized through CYP1B1 into 4-OHE1(E2) and the estrogen quinones can potentially be bad if your body has slower phase II (COMT, GSTP1, GSTM1, NQO1) enzymes.[ref][ref] The connection between smoking and estrogen-related cancers: Smoking significantly increases the risk of breast cancer and prostate cancer