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Redox homeostasis is a key determinant of neuronal integrity and response to oxidative stress, and these findings are consistent with earlier observations in NPH, including lipid peroxidation and thiol imbalance 56 , as well as broader evidence linking glutathione-related pathways to neurodegeneration and aging 5759
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Participants were required to abstain from alcohol from 24 hours before until 24 hours after each dosing, refrain from caffeine and nicotine on imaging visit days and not drive or operate machinery from the time of dosing until 24 hours postdose