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doi: 10.1016/j.ejps.2025.107073 Summary Keywords hepatoprotection, hepatotoxicity, morin, nano-formulations, oxidative stress, synergistic therapy Citation Sivalingam AM (2026) Crosstalk along the gut-liver axis modulates glutathione and cadmium-induced hepatotoxicity

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To obtain stable SLC25A39 knockdown cells, Huh7 cells were transfected with lentivirus carrying a shRNA targeting SLC25A39 (shRNA-SLC25A39, 5-GTGGTTACCTCTCTCTTCATG-3) or negative control (sh-NC, 5-TTCTCCGAACGTGTCACGT-3)

The proposed mechanism involves melatonin's action on hypothalamic GHRH neurons and its mild somatostatin-suppressive effect

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