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These areas are accessible to circulating peripheral GLP-1 and thus may permit direct effects of this peptide in the central nervous system (CNS)

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New England Journal of Medicine , v

It is also contraindicated in individuals who take chronic opioid medications, as naltrexone blocks opioid receptors and can interfere with pain control

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GLP-1 Engineering for Brain Access: DPP4 site mutations plus lipid conjugation enable albumin binding, extend half-life, and raise brain exposure