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Described herein are otic formulations or compositions with an ionic balance that is compatible with the perilymph and/or the endolymph and does not cause any change in cochlear potential

Translation into clinical applications remains an unresolved question

Astroglial pathophysiology can be broadly classified into: (i) Astroglial reactivity or reactive astrogliosis

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Based on KEGG metabolic libraries, metabolic pathways with significant differences in metabolites were identified